Semantic characterization of adverse outcome pathways

Revised Guidance Document on Developing and Assessing Adverse Outcome Pathways

Adverse Outcome Pathways-Organizing Toxicological Information to Improve Decision Making.

The number of chemicals for which environmental regulatory decisions are required far exceeds the current capacity for toxicity testing. High-throughput screening commonly used for drug discovery has the potential to increase this capacity. The adverse outcome pathway (AOP) concept has emerged as a framework for connecting high-throughput toxicity testing (HTT) and other results to potential im...

The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

In conjunction with the second International Environmental Omics Symposium (iEOS) conference, held at the University of Liverpool (United Kingdom) in September 2014, a workshop was held to bring together experts in toxicology and regulatory science from academia, government and industry. The purpose of the workshop was to review the specific roles that high-content omics datasets (eg, transcrip...

Apparent adverse outcome of acupuncture.

Alternative and complementary medical care are becoming increasingly popular in the United States, although many patients continue to consult mainstream physicians as well. As a result, physicians are seeing an increasing number of interactions between alternative treatments and their own medical practices. Many alternative and complementary forms of medicine are not studied in a scientific or ...

Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program.

BACKGROUND The U.S. EPA's Endocrine Disruptor Screening Program (EDSP) screens and tests environmental chemicals for potential effects in estrogen, androgen, and thyroid hormone pathways, and it is one of the only regulatory programs designed around chemical mode of action. OBJECTIVES This review describes the EDSP's use of adverse outcome pathway (AOP) and toxicity pathway frameworks to orga...